药物研发MEDICAL RESEARCH

肿瘤多组学数据分析Onco-multi-omics Study

基于团队自主研发的WEAVER算法以及业界最新分析方法,开展肿瘤多组学数据测序与整合分析,包括基因组(WES/WGS)、转录组(mRNA/miRNA/LncRNA)、表观组(WGBS)和三维基因组(Hi-C)。The onset of cancer could be a combinatorial effect of molecular alterations at multiple levels including genome, epigenome, transcriptome, proteome, and metabolome. Our multi-omics approaches can facilitate the interrogation of the molecular mechanism underlying different cancer types and dissecting the ceullular responses to chemo- or immunotherapy.

基因组分析包括突变位点注释、CNV/SV分析、肿瘤驱动/高频突变分析。转录组分析包括可变剪切分析、差异表达分析、基因功能注释等。表观组分析包括甲基化图谱、组蛋白结合位点、甲基化差异分析等。三维基因组分析染色体互作、染色体顺反式相互作用等。Our cancer research platform incorporates advanced pathology and molecular biology techniques, the proprietary WEAVER algorithms, as well as industry-standard bioinformatics analysis softwares, and we provide all-around solutions including genomic analysis (variant calling and annotation, CNV/SV analysis, mutation profiling for oncogene, tumor mutation burden, etc.), transcriptome analysis (alternative splicing, differential expression, etc.), epigenetic analysis (DNA methylation state, DNA-histone interaction, chromatin assembly analysis), and the study of 3D chromosomal structure and interaction.

宏基因组分析Metagenomics Research

宏基因组研究以环境中所有微生物基因组为研究对象,通过对环境样品中的全基因组DNA进行高通量测序,获得单个样品的饱和数据量,进一步研究微生物群落结构多样性,微生物群体基因组成及功能,特定环境相关的代谢通路等分析,从而进一步发掘和研究具有应用价值的基因及环境中微生物群落内部、微生物与环境间的相互关系。 Metagenomics is the study of all the genetic materials in a sample, it's clinical application usually involves the sequencing and characterizing of all the microorganism is a patient's sample, and to study the associations between microorganism compositions and health conditions. Metagenomics have the potential to expand the application of clinical microbiology, and provide insights into many other clinical fields.

基于最新的生物信息学算法,安吉康尔提供Denovo组装、基因预测、基因集功能注释、物种多样性分析等个性化分析服务。目前该流程已经应用于包括多动症在内的多项科研项目研究中。Our metagenomic research platform provides de novo assembly, gene finding, gene cluster analysis, abundance and diversity analysis, and several collaborations have been going on to study the relationship between micro-organism polulation and ADHD, epilepsy, autism etc.

转录组测序分析Transcriptome Analysis

转录组测序是对某一物种或特定细胞在某一功能状态下产生的mRNA进行高通量测序,可以提供定量分析,检测基因表达水平差异;也可以验证基因层面的突变对于剪切的影响。转录组测序广泛应用于复杂疾病研究、癌症研究与机制确定、药物发现研究等。RNA-seq is the most recent transcriptomic approach where the RNA in a sample is isolated and sequenced using high-throughput sequencing technologies. The population of RNA that can be sequenced and analyzed include messenger RNA (mRNA), long non-coding RNA (lncRNA), circular RNA (cirRNA), small RNA etc.

基于最新的生物信息学算法,安吉康尔提供mRNA定量分析、可变剪切分析、基因差异表达与功能注释、蛋白质网络构建、基因转录调控分析等分析服务。Our transncriptome reserach platform provides comprehensive analysis on RNA quantification, variant calling, alternative splicing analysis, differential expression analysis, transcription regulation analysis.

单细胞测序与分析Single Cell Sequencing

基于10x genomics单细胞转录组和VDJ平台,开展单细胞转录组以及免疫组库测序与定制化数据分析解读服务。数据基础分析包括细胞分群,细胞亚群鉴定,基因差异表达分析与功能注释等。高级数据分析包括伪时间树构建、cell-cell crosstalk、转录调控预测、转录组与TCR/BCR整合分析等。Based on the 10x Genomics platform, the single cell sequencing examines the sequence information from individual cells with next generation sequencing technology. It can be used for cell population analysis, immune profilling, expression measurement, microenvironment characterization etc.